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. 2020 Nov 5;12(11):3270. doi: 10.3390/cancers12113270

Figure 1.

Figure 1

Concordant transcriptome–proteome differential expression of grade III vs. grade I meningiomas. (a) Scatterplot displaying 3598 genes commonly identified in a transcriptomic microarray analysis including 13 non-recurrent grade I meningiomas and 20 malignant grade III meningiomas and a global proteomic analysis including eight grade I and six grade III meningiomas [12,19]. Pearson’s correlation coefficient revealed a modest, yet highly significant correlation of r = 0.35, p = 3.6 × 10−104. Log2 fold changes (LFC) at the transcript and protein level of overlapping genes are shown for grade III vs. grade I meningiomas. The top 10 genes based on average rank value exhibiting concordantly increased or decreased LFC between the two datasets are highlighted in red or green, respectively. (b,c) Top 10 genes showing concordantly increased (b) or decreased (c) LFC in grade III vs. grade I meningiomas are presented with respective LFC, rank and average rank values. Table S3A provides details of all 3598 genes common to both analyses, transcript/protein LFC, their rank and average rank.