. 2020 Nov 5;9(11):3561. doi: 10.3390/jcm9113561

Table 2.

Details of genes encoding cytokines and their receptors associated with HBV and MMR vaccine efficacies and safety.

Gene	Gene Description	Genomic Location	Gene Product Function	Associated Disease Phenotypes–Not Vaccine Related [28]	Studies on Associated Vaccinomic Phenotypes		Studies on Associated Adversomics Phenotypes
Gene	Gene Description	Genomic Location	Gene Product Function	Associated Disease Phenotypes–Not Vaccine Related [28]	HBV	MMR	MMR
TNF	Tumour necrosis factor	6p21.33	Cytokine, regulation of cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation	Asthma, malaria susceptibility, migraine	None	[34]	None
TNFRSF1A	TNF receptor superfamily member 1A	12p13.31	TNF receptor, cell survival, apoptosis, and inflammation	Intermittent hydrarthrosis, multiple sclerosis, familial periodic fever, TNF receptor 1 associated periodic syndrome	None	[34]	None
IL-6	Interleukin 6	7p15.3	Cytokine, inflammation, and maturation of B cells	Arteriovenous malformations of the brain, diabetes mellitus type I, Crohn’s disease, Kaposi sarcoma, juvenile rheumatoid arthritis, juvenile idiopathic arthritis	None	[34]	None
IL-1β	Interleukin 1β	2q14.1	Cytokine, mediator of inflammatory responses	Gastric cancer risk (Helicobacter pylori induced), periodontal disease	[27]	[34]	None
IL-13	Interleukin 13	5q31.1	Cytokine, B cell maturation, promotion of IgE isotype switching of B cells	Asthma, allergic rhinitis	[27]	None	None
IL-4	Interleukin 4	5q31.1	Cytokine, B cell activation, IgE secretion	Allergic bronchopulmonary aspergillosis, schistosomiasis	[27]	None	None
IL4RA	Interleukin 4 receptor	16p12.1	Receptor for IL-4 and IL-13, promotes Th2 differentiation	Atopy, human immunodeficiency virus -1 resistance	[27]	None	None
IL2RA	Interleukin 2 receptor subunit α	10p15.1	Part of IL-2 receptor, T cell-mediated immune responses	Diabetes mellitus type I, immunodeficiency, juvenile idiopathic arthritis	None	[34]	None
IL2RB	Interleukin 2 receptor subunit β	22q12.3	Part of IL2 receptor, T cell-mediated immune response	Juvenile idiopathic arthritis, immunodeficiency	None	[34]	None
IFNB1	Interferon β1	9p21.3	Cytokine, defense against viral infections, cell differentiation, anti-tumor defense	Multiple sclerosis	None	[34]	None
INFAR1	Interferon α/β receptor subunit 1	21q22.11	One of two chains of a receptor for INFα and INFβ, activation of receptor stimulates Janus protein kinases, which phosphorylate STAT1 and STAT2	Hepatitis C susceptibility, measles susceptibility	None	None	[35]
INFAR2	Interferon α/β receptor subunit 2	21q22.11	One of two chains of a receptor for INFα and INFβ, activation of receptor stimulates Janus protein kinases, which phosphorylate STAT1 and STAT2	Measles susceptibility, immunodeficiency 45	None	None	[36]