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. 2020 Nov 5;9(11):3561. doi: 10.3390/jcm9113561

Table 4.

Details of other genes associated with HBV and MMR vaccine efficacies and safety.

Gene Gene Description Genomic Location Gene Product Function Associated Disease Phenotypes–Not Vaccine Related [28] Studies on Associated Vaccinomic Phenotypes Studies on Associated Adversomics Phenotypes
HBV MMR MMR
CD46 CD46 molecule 1q32.2 Cofactor activity for inactivation of complement components C3b and C4b by serum factor I Atypical hemolytic uremic syndrome with complement gene abnormality, hemolysis, elevated liver enzymes, and a low platelet count syndrome None [46,47] [7]
BTNL2 Butyrophilin-like 2 6p21.32 MHC-II-associated, transmembrane protein, negative T cell regulator Sarcoidosis, multiple sclerosis, autism/schizophrenia [22,23,25] None None
SLAM Signaling lymphocytic activation molecule family member 1 1q23.3 Self-ligand receptor of signaling lymphocytic activation molecule, modulating the activation and differentiation of a wide variety of immune cells Measles susceptibility, subacute sclerosing panencephalitis None [47] None
IFI44L Interferon-induced protein 44 like 1p31.1 Unknown, shown a low antiviral activity against hepatitis C virus Lymph node tuberculosis, Aicardi-Goutieres syndrome None [46] [7]
TLR4 Toll-like receptor 4 9q33.1 Pathogen recognition and activation of innate immunity Behcet’s disease None [48] None
TLR2 Toll-like receptor 2 4q31.3 Pathogen recognition and activation of innate immunity Leprosy susceptibility, tuberculosis susceptibility [27] [48] None
KIAA1542 PHD and ring finger domains 1 11p15.5 Protein domain-specific binding and RNA polymerase binding Systemic lupus erythematosus None [48] None
TRIM5 Tripartite motif-containing 5 11p15.4 E3 ubiquitin-ligase, may have role in retroviral restriction Rubella susceptibility, immune deficiency disease None [38] None
TRIM22 Tripartite motif-containing 22 11p15.4 Mediates interferon antiviral effects Rubella susceptibility, hepatitis B susceptibility None [38] None
SCN1A Sodium voltage-gated channel α subunit 1 2q24.3 Sodium channel α subunit, regulates sodium exchange between intracellular and extracellular spaces, generation of action potentials in muscle cells and neurons Dravet syndrome, early infantile epileptic encephalopathy 6, familial or sporadic hemiplegic migraine, generalized epilepsy with febrile seizures plus (type 2), Lennox-Gastaut syndrome None None [7]
SCN2A Sodium voltage-gated channel α subunit 2 2q24.3 Sodium channel α subunit, regulates sodium exchange between intracellular and extracellular spaces, generation of action potentials in muscle cells and neurons Benign familial infantile epilepsy, benign familial neonatal-infantile seizures, Dravet syndrome, early infantile epileptic encephalopathy, generalized epilepsy with febrile seizures-plus, West syndrome None None [7]
ANO3 Anoctamin 3 11p14.2 Membrane protein, Ca2+-activated chloride channel Cranio-cervical dystonia with laryngeal and upper-limb involvement None None [7]