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. 2020 Nov 27;11:512. doi: 10.1186/s13287-020-02029-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — PD-MSCs^PRL-1 using a nonviral system enhances hepatic function by regulating mitochondrial metabolism in a rat BDL model. a Western blotting of albumin and human PRL-1 gene expression by PD-MSC^PRL-1 transplantation in pooled BDL-injured rat liver tissue (n = 5). b mRNA expression of albumin in a rat model with pooled BDL liver tissue (n = 5). Protein expression of the c Rho family (ROCK1 and RhoA), cell cycle (CDK4 and Cyclin D1), and mitochondrial metabolism (PDH, SDHA, ATP5B, and PHB1) by PD-MSC^PRL-1 transplantation in pooled BDL-injured rat liver tissue (n = 5). e mtDNA copy number in BDL-injured rat liver tissue by the TaqMan assay. Rat nuclear DNA was used as an internal control. f ATP production assay in rat BDL liver lysate (10 μg/μl). Data from each group are presented as the mean ± SD. ^*p < 0.05 versus NTx group; ^#p < 0.05 versus TTx naïve group. CDK4; cyclin-dependent kinase 4, Con, control group; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; NTx, nontransplantation group; PDH, pyruvate dehydrogenase; PHB1, prohibitin 1; PRL-1, phosphatase of regenerating liver-1; SDHA, succinate dehydrogenase; TTx, transplantation group