Fig. 6.
Preservation of photoreceptor function by the IL-1R modulator rytvela in light-exposed mice. Animals were exposed to blue light and treated as described in Fig 1. Flash intensities of 0.01, 0.1, 0.5, 1, and 3 cds/m2 were used in ERG analysis. Quantification of a a-wave amplitude and b b-wave amplitude of control, and blue light–exposed (BLE) mice treated or not with rytvela or Kineret. Data are expressed as mean ± SEM and analyzed using one-way ANOVA with Holm-Sidak corrections for multiple comparisons; n = 6–7 per group. ****p < 0.0001, ***p < 0.001, **p < 0.01 rytvela compared with vehicle. ##p < 0.01, #p < 0.05 Kineret compared with vehicle. c Representative waveforms of the electroretinogram recording at the flash intensity 3 cds/m2 from non-illuminated animals (control) and from blue light–exposed mice treated with vehicle, rytvela, or Kineret