Table 3. Genetic variations in FURIN and their way to modulate severe acute respiratory syndrome coronavirus-2 entry to host cell.

FURIN gene	Variation	MAF	Effect on protein, virus interaction or infection	Ref.
Genetic variations	rs4932178C >T	T: 14–40%	Approximately threefold increase in the transcriptional activity of the allele T promoter Increased risk of developing persistent HBV infection	[53]
	rs17514846C >A, G, T	A: 14–49%	Increased furin expression in vascular endothelial cells	[51]

HBV: Hepatitis B Virus; MAF: Minor Allele Frequency.