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. 2020 Nov 5;10(11):1513. doi: 10.3390/biom10111513

Figure 1.

Figure 1

Effects of eugenol on voltage-gated sodium channel currents in small-sized TG neurons. Long-time base recordings of voltage-gated sodium channel (VGSC) currents measured during 80 ms-voltage steps from a holding potential of −60 mV to a potential of 0 mV delivered every 3 s. (A) Representative VGSC current recording following the application of 0.3 mM eugenol and (B) 2 mM eugenol. (C) Percentage inhibition of VGSC currents by eugenol in capsaicin-sensitive TG neurons (from 0.1 to 2 mM, n = 37). (D) Representative VGSC current recording following the application of 0.3 mM eugenol and (E) 2 mM eugenol. (F) Proportion of VGSC current inhibition effected by eugenol (from 0.1 to 2 mM, n = 29) in capsaicin-insensitive TG neurons. * p < 0.05 versus control (no treatment).