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. 2020 Nov 5;12(11):1263. doi: 10.3390/v12111263

Table 1.

WHO 2016 interim case definitions for confirmed and suspected Zika virus infection.

Case Definition Description
Confirmed case A person with laboratory confirmation of recent Zika virus infection:

  • Presence of Zika virus RNA or antigen in serum or other samples (e.g., saliva, tissues, urine, whole blood); or

  • IgM antibody against ZIKV positive PRNT90 for ZIKV with titer ≥ 20 and ZIKV PRNT90titer ratio ≥ 4 compared to other flaviviruses; and exclusion of other flaviviruses
Suspected case A person presenting with rash and/or fever and at least one of the following signs or symptoms:

  • Arthralgia; or

  • Arthritis; or

  • Conjunctivitis (non-purulent/hyperemic)