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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Clin Transplant. 2020 Apr 25;34(6):e13827. doi: 10.1111/ctr.13827

TABLE 3.

Summary of SNPs with full model meta-analysis P-values ≤ 7.5 × 10−7 after accounting for the effect of APOL1

Discovery (Wake Forest, UAB, Emory) Validation (DeKAF Genomics) Meta-Analysis
SNP Chromosome Position Nearest Gene Alleles MAF Estimate SE P-value Estimate SE P-value Estimate P-value DE I2
rsl923418 6 89 267 044 RNGTT C/A 0.197 0.54 0.11 6.5 × 10−7 0.27 0.23 0.23 0.49 5.5 × 10−7 + + 0.08
rsl2552330 9 21380 237 PIPSL A/C 0.078 0.70 0.13 2.2 × 10−7 0.15 0.31 0.63 0.61 7.5 × 10−7 + + 0.62
rs2113955 10 95 669 893 SLC35G1 G/C 0.492 −0.52 0.10 1.9 × 10−7 0.16 0.21 0.43 −0.39 1.5 × 10−5 − + 0.89
rsll3665227 11 106 277 946 G/A 0.086 0.68 0.14 6.4 × 10−7 0.74 0.47 0.11 0.68 1.8 × 10−7 + + 0.00
rs9319516 16 77 782 258 NUDT7 G/A 0.139 0.65 0.12 5.7 × 10−8 0.14 0.28 0.63 0.57 2.2 × 10−7 + + 0.65

Note: Estimate, Coefficient estimate associated with the SNP in the model; SE, standard error; DE, direction of effect; I2, A measure of heterogeneity between studies; Adjustment, APOL1 genotype and the individual admixture proportion.