TABLE 4.
Summary of SNPs-by-APOL1 interactions with full model meta-analysis P-values ≤ 7.5 × 10−7
| Discovery (Wake Forest, UAB, Emory) | Validation (DeKAF Genomics) | Meta-Analysis | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Chromosome | Position | Nearest Gene | Alleles | MAF | Estimate | SE | P-value | Estimate | SE | P-value | Estimate | P-value | Sign | I2 |
| rsl695847 | 1 | 1431806 | ATAD3B | A/C | 0.09 | −3.99 | 0.80 | 6.4 × 10−7 | −1.34 | 3.90 | 0.73 | −3.88 | 7.2 × 10−7 | — | 0.00 |
| rs76455983 | 2 | 53 105 036 | G/T | 0.09 | 1.44 | 0.28 | 2.8 × 10−7 | 2.21 | 0.96 | 0.02 | 1.50 | 2.5 × 10−8 | ++ | 0.00 | |
| rs7582966 | 2 | 104 018 063 | C/T | 0.49 | −1.27 | 0.24 | 1.6 × 10−7 | 0.13 | 0.88 | 0.89 | −1.17 | 5.4 × 10−7 | −+ | 0.57 | |
| rs6906957 | 6 | 108 206 385 | SEC63 | A/G | 0.23 | 1.58 | 0.26 | 2.0 × 10−9 | 0.87 | 0.64 | 0.18 | 1.48 | 1.3 × 10−9 | ++ | 0.03 |
| rs73710129 | 8 | 129 073 950 | PVT1 | T/C | 0.12 | 1.46 | 0.27 | 4.1 × 10−8 | −0.15 | 0.64 | 0.82 | 1.22 | 6.5 × 10−7 | +− | 0.81 |
| rs4889062 | 16 | 80 018 950 | A/G | 0.29 | 1.41 | 0.27 | 1.3 × 10−7 | 0.43 | 0.86 | 0.62 | 1.32 | 2.1 × 10−7 | ++ | 0.15 | |
Note: Estimate, Coefficient estimate associated with the SNP-by-APOLl interaction term in the model; SE, standard error; DE, direction of effect; I2, A measure of heterogeneity between studies; Adjustment, individual admixture proportion, ages of the donor and the recipient, sex, recipient race, transplant center, HLA match, cold ischemia time, panel reactive antibodies, donor age, and donor type (standard donor vs extended-criteria donor).