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. 2020 Nov 25;218(3):e20201173. doi: 10.1084/jem.20201173

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Figure S2. — Fas is up-regulated in EAB cells. (A and B) MD4 BoyJ mice were given a mixture of CTV-labeled splenocytes that were 20% Fas^lpr/lpr and 80% WT (CD45.1/2). Histograms show Fas expression among transferred naive cells, EAB cells, or GC B cells that were Fas^lpr/lpr (red) or WT (CD45.1/2; gray) in mLNs 5 d after transfer (A). Frequency of Fas^lpr/lpr (CD45.2⁺) among transferred cells that were naive, EAB, or GC B cells in mLNs 5 d after transfer (B). Data are from one experiment with three mice representative of two independent experiments. (C) Intracellular FACS for active caspase-3 in LZ or DZ GC B cells from PPs of Cr2-cre Fas^f/f mixed BM chimeras generated as in Fig. 1 F, analyzed directly ex vivo. Data are from two independent experiments with 10 mice total per group. *, P < 0.05, paired two-tailed Student’s t test.