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. 2020 Nov 25;218(3):e20201173. doi: 10.1084/jem.20201173

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Figure S4. — Frequency of GC B cells in pLNs of unimmunized Fas-deficient mice. (A and B) Frequency of GC B cells among total cells in unimmunized pLNs from littermate control or Cr2-cre Fas^f/f animals (A) or Aicda^cre/+Fas^f/+ or Aicda^cre/+Fas^f/f animals (B). Data are from four and three independent experiments, respectively, with one to four mice per group. (C and D) Intracellular FACS for active caspase-3 in non–NP-binding or NP-binding LZ or DZ GC B cells from pLNs of Aicda^cre/+Fas^f/+ or Aicda^cre/+Fas^f/f animals 12 d following s.c. immunization with NP-CGG in alum. Data are from three independent experiments with three to six animals per group. ***, P < 0.001, unpaired two-tailed Student’s t test, for data in A. **, P < 0.01; ***, P < 0.001; ****, P < 0.0001, paired two-tailed Student’s t test, for data in C and D comparing non–NP-binding with NP-binding cells. *, P < 0.05, unpaired two-tailed Student’s t test, for data in C comparing non–NP-binding cell control and Aicda^cre/+Fas^f/f animals.