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. 2020 Oct 23;98(11):skaa345. doi: 10.1093/jas/skaa345

Table 4.

Hematology variables (Lsmean with pooled SE) in 153 weaned beef calves according to combined classification at three sampling timepoints

Hematology parameter1 Combined classification2 Time 13 Time 24 Time 35 SE Treatment6 (Trt) Time (T) Trt × T
WBCs,
×103 cells/µL		 Healthy 10.4 9.7 9.1 0.34 0.0037 0.3366 0.4437
sBRD 10.3 10.1 — 0.78
BRD-no-con 10.8 10.4 10.1 0.51
BRD-con 10.7 10.8 11.2 0.45
Neutrophils,
×103 cells/µL		 Healthy 3.1 2.6x 2.2x 0.26 0.001 0.1136 0.0018
sBRD 2.7 2.1x – 0.56
BRD-no-con 2.9 3.8xy 2.6xy 0.38
BRD-con 2.7a 4.1b,y 3.8ab,y 0.33
Lymphocytes,
×103 cells/µL		 Healthy 6.9 6.6 6.5 0.21 0.1952 0.0062 0.1241
sBRD 7.1 7.4 7.6 0.48
BRD-no-con 7.6 6.3 7.0 0.32
BRD-con 7.6 6.3 6.9 0.28
N:L Healthy 0.46 0.40x 0.36x 0.05 0.0002 0.0448 0.0004
sBRD 0.39 0.31x – 0.10
BRD-no-con 0.42 0.63xy 0.41xy 0.07
BRD-con 0.36a 0.69b,y 0.62b,y 0.06
Basophils,
×103 cells/µL		 Healthy 0.12 0.12xy 0.12 0.006 0.0334 0.0029 0.0196
sBRD 0.13 0.14x 0.15 0.013
BRD-no-con 0.12 0.09y 0.13 0.009
BRD-con 0.12a 0.11a,xy 0.14b 0.007
Monocytes,
×103 cells/µL		 Healthy 0.45 0.41 0.37 0.023 0.1376 0.1685 0.7377
sBRD 0.44 0.49 – 0.053
BRD-no-con 0.46 0.46 0.40 0.035
BRD-con 0.48 0.44 0.46 0.031
Eosinophils,
×103 cells/µL		 Healthy 0.27 0.22 0.25 0.035 0.0935 0.3718 0.1847
sBRD 0.21 0.42 0.33 0.082
BRD-no-con 0.24 0.16 0.33 0.055
BRD-con 0.17 0.17 0.21 0.048
RBCs,
×106 cells/µL		 Healthy 10.7 10.6 10.5 0.16 0.001 0.1131 0.7346
sBRD 10.6 10.4 – 0.37
BRD-no-con 10.5 10.1 10.6 0.24
BRD-con 10.3 9.6 9.9 0.21
Hemoglobin,
g/dL		 Healthy 13.8 13.5 13.5 0.21 0.0072 0.0206 0.8926
sBRD 13.6 13.3 – 0.44
BRD-no-con 13.6 12.9 13.2 0.30
BRD-con 13.5 12.6 12.9 0.27
Hematocrit,
%		 Healthy 36.2 35.3 34.9 0.55 0.0107 0.0058 0.8440
sBRD 35.8 34.7 – 1.19
BRD-no-con 35.6 33.5 34.6 0.80
BRD-con 35.4 33.0 33.5 0.71
Platelets,
×103 cells/µL		 Healthy 503.3x 541.3 556.1x 22.1 <0.0001 0.0132 0.0281
sBRD 692.8y 648.5 – 51.5
BRD-no-con 560.4xy 528.0 609.6xy 33.9
BRD-con 540.2a,xy 539.6a 714.7b,y 29.5

1WBCs, white blood cells; N:L, neutrophils:lymphocytes; RBCs, red blood cells.

2Classification is based on the combination of CRS and TUS score. Healthy (n = 68), sBRD (n = 14), BRD-no-con (n = 38), and BRD-con (n = 30). A matched healthy control calf corresponding to each individual BRD case was selected retrospectively from the nearest pen to compare hematology variables at the same sample times.

3Seven days before BRD detection.

4Day of BRD diagnosis.

5Seven days of BRD detection.

6Treatment (TRT) refers to classification groups (Healthy, sBRD, BRD-no-con, and BRD-con).

a–cWithin rows, Lsmeans differ from pre-BRD baseline by P ≤ 0.05.

x–zWithin columns, Lsmeans differ between treatments by P ≤ 0.05.

Lsmeans with the same letter are not significantly different.