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. 2020 Nov 6;10(11):1519. doi: 10.3390/biom10111519

Figure 5.

Figure 5

Expression of striatal inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as measured by Western blot analysis (A,C). A significant increase in iNOS was observed in the MPTP group relative to the control (Vehicle + Saline) group. Ellagic acid (EA) treatment prior to MPTP injection significantly decreased the expression of iNOS relative to the MPTP group (A,B). Similarly, COX-2 expression was increased significantly in MPTP group relative to the control (Vehicle + Saline) group. EA treatment decreased the COX-2 expression relative to the MPTP group (C,D). Values are expressed as percentage of mean ± SEM relative to control group (Vehicle + Saline). Significance is denoted as * p < 0.05, ** p < 0.01 and *** p < 0.001.