Table 6.
Short chain fatty acid (SCFA) concentration (mmol SCFA/kg human faeces) from the metabolomics analysis in healthy participants.
| SCFA Concentration (µmol SCFA/g Human Faeces) | Sucralose Treatment | Aspartame Treatment | ||||
|---|---|---|---|---|---|---|
| Pre-Sucralose | Post-Sucralose | p-Value * | Pre-Aspartame | Post-Aspartame | p-Value * | |
| Acetate | 46.13 ± 4.97 | 55.37 ± 12.92 | 0.49 | 61.76 ± 15.47 | 69.08 ± 20.84 | 0.79 |
| Propionate | 15.48 ± 2.11 | 20.35 ± 5.04 | 0.39 | 27.83 ± 9.69 | 33.24 ± 13.37 | 0.75 |
| Butyrate | 9.95 ± 1.21 | 11.17 ± 2.32 | 0.60 | 12.47 ± 2.34 | 14.78 ± 2.87 | 0.56 |
| Isovaleric acid | 2.01 ± 0.27 | 2.01 ± 0.33 | 0.99 | 2.67 ± 0.58 | 1.86 ± 0.25 | 0.14 |
| Valeric acid | 1.64 ± 0.36 | 1.38 ± 0.28 | 0.34 | 1.51 ± 0.35 | 2.80 ± 0.74 | 0.13 |
| Hexanoic acid | 0.30 ± 0.14 | 0.27 ± 0.08 | 0.78 | 0.31 ± 0.13 | 0.20 ± 0.08 | 0.38 |
Values are expressed as the mean ± standard error (SE), n = 14–16. * A linear mixed-effects model was used to test statistical significance.