Table 4.
Genotype and allele distribution of the polymorphisms of autophagy-related genes in wet AMD patients and controls.
| Genotype/Allele | Frequency | Crude OR (95% CI) | p | Adjusted OR 1 (95% CI) | p | |
|---|---|---|---|---|---|---|
| Control | AMD | |||||
| rs2295080 148/216 (Control/AMD cases) | ||||||
| GG | 0.12 | 0.12 | 1.07 (0.57–2.00) | 0.836 | 1.28 (0.65–2.53) | 0.474 |
| GT | 0.32 | 0.42 | 1.51 (0.98–2.34) | 0.062 | 1.49 (0.94–2.38) | |
| TT | 0.56 | 0.46 |
0.661 (0.435–1.004)
0.664 (0.454–0.971) 2 |
0.052
0.035 |
0.621 (0.398–0.968)
2 0.617 (0.393–0.968)0.651 |
0.035
0.036 |
| G | 0.22 | 0.27 | 1.296 (0.941–1.785) | 0.113 | ||
| T | 0.28 | 0.23 | 0.772 (0.560–1.063) | 0.113 |
0.709 (0.503–0.998)
2 0.703 (0.493–0.995)0.725 |
0.048
0.049 |
| rs11121704 152/209 (Control/AMD cases) | ||||||
| CC | 0.07 | 0.09 | 1.15 (0.53–2.52) | 0.720 | 1.23 (0.54–2.82) | 0.616 |
| CT | 0.26 | 0.33 | 1.489 (0.940–2.357) 1.481 (0.936–2.345) 2 |
0.089 0.093 2 |
1.609 (0.985–2.628) 2 1.634 (0.982–2.717)0.459 |
0.056 0.059 |
| TT | 0.67 | 0.58 | 0.671 (0.436–1.034) 0.663 (0.433–1.016) 2 |
0.071 0.059 2 |
0.613 (0.386–0.972)
2 0.605 (0.375–0.975)0.717 |
0.037
0.039 |
| C | 0.16 | 0.21 | 1.34 (0.94–1.91) | 0.102 | 1.447 (0.993–2.109) 2 1.467 (1.016–2.119)0.479 |
0.054 0.041 |
| T | 0.33 | 0.29 | 0.74 (0.52–1.06) | 0.102 | 0.691 (0.474–1.007) 2 0.681 (0.474–0.985)0.809 |
0.054 0.041 |
| rs1057079 161/217 (Control/AMD cases) | ||||||
| CC | 0.07 | 0.10 | 1.47 (0.71–3.04) | 0.293 | 1.69 (0.77–3.71) | 0.191 |
| CT | 0.33 | 0.41 | 1.37 (0.90–2.10) | 0.141 | 1.39 (0.88–2.18) | 0.153 |
| TT | 0.60 | 0.49 |
0.653 (0.434–0.984)
0.654 (0.435–0.982) 2 |
0.041
0.041 2 |
0.621 (0.402–0.961)
2 0.620 (0.396–0.972)0.675 |
0.032
0.037 |
| C | 0.20 | 0.25 |
1.413 (1.021–1.955)
1.403 (1.017–1.936) 2 |
0.037
0.039 2 |
1.500 (1.059–2.123)
2 1.507 (1.059–2.144)0.612 |
0.022
0.023 |
| T | 0.30 | 0.25 |
0.708 (0.511–0.979)
0.707 (0.513–976) 2 |
0.037
0.035 2 |
0.667 (0.471–0.944)
2 0.661 (0.470–0.929)0.869 |
0.022
0.017 |
| rs1064261 138/215 (Control/AMD cases) | ||||||
| GG | 0.09 | 0.09 | 0.94 (0.45–1.96) | 0.874 | 0.98 (0.45–2.13) | 0.961 |
| GA | 0.30 | 0.37 | 1.42 (0.90–2.24) | 0.131 | 1.50 (0.92–2.44) | 0.101 |
| AA | 0.61 | 0.53 | 0.74 (0.48–1.14) | 0.174 | 0.70 (0.44–1.10) | 0.123 |
| G | 0.19 | 0.23 | 1.19 (0.85–1.68) | 0.313 | 1.25 (0.87–1.80) | 0.229 |
| A | 0.30 | 0.27 | 0.84 (0.59–1.18) | 0.313 | 0.80 (0.55–1.15) | 0.230 |
| rs573775 160/214 (Control/AMD cases) | ||||||
| AA | 0.14 | 0.07 |
0.492 (0.253–0.954)
0.487 (0.246–0.964) 2 |
0.036
0.039 2 |
0.611 (0.304–1.227) | 0.165 |
| AG | 0.44 | 0.53 | 1.42 (0.94–1.14) | 0.092 2 | 1.31 (0.85–2.03) | 0.221 |
| GG | 0.42 | 0.40 | 0.92 (0.61–1.39) | 0.699 | 0.92 (0.59–1.43) | 0.717 |
| A | 0.29 | 0.30 | 0.90 (0.67–1.21) | 0.493 | 0.94 (0.68–1.29) | 0.707 |
| G | 0.21 | 0.20 | 1.11 (0.82–1.50) | 0.493 | 1.06 (0.77–1.46) | 0.707 |
| rs11246867 161/217 (Control/AMD cases) | ||||||
| AA | 0.00 | 0.00 | 2.1 × 107 (0–0) | 0.997 | 1.6077 × 1010 (0–0) | 1.000 |
| AG | 0.15 | 0.15 | 0.98 (0.55–1.72) | 0.933 | 0.95 (0.52–1.73) | 0.860 |
| GG | 0.85 | 0.85 | 0.99 (0.56–1.40) | 0.970 | 1.00 (0.55–1.83) | 0.994 |
| A | 0.07 | 0.08 | 1.04 (0.61–1.79) | 0.881 | 1.05 (0.59–1.85) | 0.878 |
| G | 0.42 | 0.42 | 0.96 (0.56–1.65) | 0.881 | 0.96 (0.54–1.69) | 0.878 |
| rs3088051 149/216 (Control/AMD cases) | ||||||
| CC | 0.07 | 0.05 | 0.71 (0.30–1.73) | 0.455 | 0.69 (0.26–1.84) | 0.462 |
| CT | 0.36 | 0.38 | 1.10 (0.72–0.69) | 0.665 | 1.13 (0.71–1.80) | 0.599 |
| TT | 0.58 | 0.57 | 0.98 (0.65–1.50) | 0.941 | 0.96 (0.61–1.50) | 0.855 |
| C | 0.21 | 0.22 | 0.96 (0.68–1.35) | 0.822 | 0.98 (0.68–1.41) | 0.903 |
| T | 0.29 | 0.29 | 1.04 (0.74–1.46) | 0.822 | 1.02 (0.71–1.48) | 0.903 |
| rs73105013 156/210 (Control/AMD cases) | ||||||
| CT | 0.21 | 0.18 | 0.79 (0.47–1.32) | 0.366 | 0.73 (0.42–1.23) | 0.252 |
| TT | 0.76 | 0.82 | 1.53 (0.92–2.53) | 0.102 | 1.65 (0.96–2.83) | 0.069 |
| C | 0.12 | 0.09 |
0.597 (0.376–0.949)
0.601 (0.376–0.960) 2 |
0.029
0.033 2 |
0.561 (0.344–0.919)
2 0.565 (0.337–0.947)0.695 |
0.021
0.030 |
| T | 0.38 | 0.41 |
1.674 (1.054–2.660)
1.686 (1.052–2.703) 2 |
0.029
0.030 2 |
1.779 (1.089–2.910)
2 1.776 (1.078–2.927)0.993 |
0.021
0.024 |
| rs10277 136/212 (Control/AMD cases) | ||||||
| CC | 0.46 | 0.35 | 0.657 (0.426–1.015) 0.656 (0.429–1.004) 2 |
0.059 0.052 2 |
0.658 (0.414–1.047) | 0.077 |
| CT | 0.41 | 0.49 | 1.34 (0.87–2.06) | 0.182 | 1.28 (0.80–2.03) | 0.297 |
| TT | 0.13 | 0.16 | 1.27 (0.68–2.38) | 0.450 | 1.41 (0.72–2.76) | 0.316 |
| C | 0.44 | 0.42 | 0.75 (0.54–1.03) | 0.071 | 0.74 (0.53–1.03) | 0.074 |
| T | 0.06 | 0.08 | 1.34 (0.97–1.36) | 0.078 | 1.36 (0.97–1.91) | 0.074 |
| rs10902469 161/217 (Control/AMD cases) | ||||||
| CG | 0.15 | 0.15 | 1.34 (0.97–1.86) | 0.934 | 0.95 (0.52–1.73) | 0.086 |
| GG | 0.85 | 0.85 | 0.99 (0.56–1.74) | 0.970 | 1.00 (0.55–1.83) | 0.994 |
| C | 0.08 | 0.08 | 1.04 (0.61–1.79) | 0.881 | 1.05 (0.59–1.85) | 0.888 |
| G | 0.42 | 0.42 | 0.96 (0.56–1.65) | 0.881 | 0.95 (0.54–1.69) | 0.880 |
1 Odds ratio (OR) adjusted for sex and the usage of antiplatelet and cholesterol-lowering drugs; for significant comparisons the 2 means the bootstrap-boosted OR (resampling with replacement, 10,000 iterations); all OR values without bootstrap analysis were calculated using the cross-validation algorithm. Statistical power; (1−β) (calculated at α = 0.05) for significant comparisons given in superscripts. p < 0.05 along with the corresponding ORs are in bold.