TABLE 1.
Baseline variables in the 2 groups
| Variable | Lyophilized | n | Cryopreserved | n | P‐value | Hypothesis test |
|---|---|---|---|---|---|---|
| Age (y) | 7.1 ± 3.5 | 50 | 7.08 ± 3.55 | 38 | .1 | t test |
| Sex (female/male) | 31/18 | 49 | 22/16 | 38 | .66 | Fisher's exact test |
| Temperature (°F) | 101.8 ± 1.2 | 49 | 101.6 ± 1.4 | 38 | .46 | t test |
| Pulse rate (bpm) | 124 ± 26 | 49 | 125.9 ± 24.9 | 38 | .71 | t test |
| Respiratory rate (rpm) | 31 (28‐36) | 36 | 36 (29‐48) | 29 | .15 | Mann‐Whitney U test |
| DOGiBAT score | 6 (4–6) | 49 | 5 (3–7) | 38 | .45 | Mann‐Whitney U test |
| Platelet count (×103/μL) | 6.0 (0.3‐14.5) | 49 | 8.9 (0.8‐12.0) | 38 | .85 | Mann‐Whitney U test |
| HCT (%) | 36.0 ± 10.9 | 49 | 36.4 ± 10.7 | 38 | .86 | t test |
| Leukocyte count (×103/μL) | 15.3 (9.7‐21.9) | 49 | 14.9 (9.2‐20.6) | 38 | .66 | Mann‐Whitney U test |
| Neutrophil count (×103/μL) | 10.8 (7.9‐17.6) | 44 | 12.5 (6.6‐17.7) | 36 | .8 | Mann‐Whitney U test |
| BMBT (s) | 600 (300‐600) | 11 | 600 (270‐600) | 7 | .68 | Mann‐Whitney U test |
| aPTT (n L/N/H) | 4/36/9 | 50 | 2/25/7 | 34 | .78 | 𝜒2 |
| PT (n L/N/H) | 3/45/2 | 50 | 1/34/1 | 36 | .74 | 𝜒2 |
| R‐time (n L/N/H) | 1/10/3 | 14 | 0/12/5 | 17 | .49 | 𝜒2 |
| K‐time (n L/N/H) | 12/1/2 | 14 | 13/2/1 | 17 | .67 | 𝜒2 |
| Alpha angle (n L/N/H) | 7/6/1 | 14 | 5/11/1 | 17 | .47 | 𝜒2 |
| MA (n L/N/H) | 12/2/0 | 14 | 14/3/0 | 17 | .8 | 𝜒2 |
| G (n L/N/H) | 9/2/0 | 11 | 12/3/0 | 15 | .9 | 𝜒2 |
| Lag time (min) | 2.6 (2.2‐2.8) | 6 | 2.7 (2.7‐2.9) | 9 | .26 | Mann‐Whitney U test |
| Peak thrombin (nM) | 88.5 (77.5‐98.9) | 6 | 91.7 (70.4‐96.9) | 9 | .95 | Mann‐Whitney U test |
| ETP (nM·min) | 422 (294‐442) | 6 | 401 (353‐460) | 9 | .78 | Mann‐Whitney U test |
Note: Parametric data are summarized by mean ± SD, non‐parametric data are summarized by median (interquartile range) and categorical data are displayed as n per category. Differences in the reference intervals for the coagulation variables between centers precluded comparison as continuous variables. Hence coagulation variables were compared as categorized variables (low, normal, or high) based on local reference intervals.
Abbreviations: aPTT, activated partial thromboplastin time; BMBT, buccal mucosal bleeding time; ETP, endogenous thrombin potential; H, above the reference interval; HCT, hematocrit; K‐time, clot formation time; L, Below the reference interval; MA, maximum amplitude; N, within the reference interval; PT, prothrombin time; R‐time, clot reaction time.