TABLE 3.
Summary of serial evaluations of coagulation variables
| T0 | T1 | T24 | ||||
|---|---|---|---|---|---|---|
| LP | CPP | LP | CPP | LP | CPP | |
|
BMBT (s) |
600 (300–600) |
600 (270‐600) |
392 (227‐600) |
495 (240‐600) |
563 (262‐600) |
182 (104‐307) |
|
PT (n L/N/H) |
3/45/2 | 1/34/1 | 5/36/1 | 0/30/0 | 0/37/1 | 0/25/4 |
|
aPTT (n L/N/H) |
5/36/9 | 2/25/7 | 2/23/15 | 1/20/7 | 4/24/9 | 2/18/4 |
|
R time (n L/N/H) |
1/11/4 | 0/12/5 | 3/6/5 | 0/6/3 | 1/6/3 | 0/6/4 |
|
K time (n L/N/H) |
13/1/2 | 13/2/1 | 10/3/2 | 7/3/2 | 8/2/0 | 9/2/0 |
|
Alpha angle (n L/N/H) |
8/7/1 | 5/11/1 | 8/5/1 | 2/7/0 | 4/5/1 | 3/7/0 |
|
MA (n L/N/H) |
14/2/0 | 14/3/0 | 13/1/0 | 7/2/0 | 8/2/0 | 6/3/1 |
|
G (n L/N/H) |
9/2/0 | 12/3/0 | 10/1/1 | 6/2/0 | 6/2/0 | 3/5/1 |
|
Lag time (min) |
2.6 (2.2–2.8) |
2.7 (2.7–2.9) |
2.4 (2.2‐3.1) |
2.6 (2.3‐2.9) |
2.0 (2.0‐2.7) |
2.4 (1.8‐2.6) |
|
Peak thrombin (nM) |
88.5 (77.5‐98.9) |
91.7 (70.4‐96.9) |
85.7 (76.9‐92.1) |
76.6 (64.7‐92.6) |
88.0 (82.3‐92.4) |
92.0 (85.9‐105.6) |
|
ETP (nM·min) |
421.6 (293.6‐442.0) |
401.4 (353.4‐460.0) |
409.3 (307.5‐435.1) |
400.8a (321.1‐442.0) |
403.5 (319.4‐424.6) |
441.1a (370.1‐454.3) |
Note: Data are presented as median (IQR) or as number (n) of values below (L), within (N) or above (H) the respective local reference interval. Variables sharing superscript letters were significantly different (P < .05) by repeated measures ANOVA or the Friedman test.
Abbreviations: aPTT, activated partial thromboplastin time; BMBT, buccal mucosal bleeding time; CPP, cryopreserved platelets; ETP, endogenous thrombin potential; K time, clot formation time; LP, lyophilized platelets; MA, maximum amplitude; PT, prothrombin time; R time, reaction time; T0, baseline immediately prior to transfusion; T1, 1‐hour post‐transfusion completion, T24, 24‐hours post‐transfusion completion.