FIGURE 7.

Urinary protein‐to‐creatinine ratio (UPC) before and after 30 days of combination therapy with enalapril and telmisartan in dogs with UPC > 0.5 at “ceiling” dosages of either medication alone. Dogs previously treated with enalapril (final dosage, 1.5 mg/kg PO q12h) had telmisartan (1 mg/kg PO q24h) added (gray circles). Dogs previously treated with telmisartan (final dosage, 3 mg/kg PO q24h) had enalapril (0.5 mg/kg PO q12h) added (closed squares). Lines connect measurements from a given individual. After addition of the second drug and prior to day 120, 4 dogs were removed from the study for percentage increase in blood creatinine >30% relative to baseline