TABLE 4.
Proportion of proteinuric dogs achieving reduction in urinary protein‐to‐creatinine ratio (UPC) ≥50% in response to treatment with PO administered enalapril or telmisartan at progressively greater dosages to target UPC ≤0.5
| Proportion of dogs achieving a ≥50% reduction in UPC | Odds ratio | P‐value | ||
|---|---|---|---|---|
| Enalapril | Telmisartan | |||
| Day 30 | 6/17 (35%) | 16/20 (80%) | 6.9 | .008 |
| Day 60 | 5/12 (42%) | 10/13 (77%) | 4.4 | .11 |
| Day 90 | 4/9 (44%) | 7/8 (88%) | 7.6 | .13 |
| Day 120 | 12/12 (100%) | 12/13 (92%) | 0 | 1 |
| Monotherapy (various dosages) | 6/6 (100%) | 9/10 (90%) | ||
| Second drug added | 6/6 (100%) | 3/3 (100%) | ||
| At maximum‐tolerated dosage | 8/16 (50%) | 16/19 (84%) | 5.1 | .06 |
Note: Dogs achieving UPC ≤0.5 at earlier time points were not reevaluated until day 120. Data are presented as number of dogs achieving the endpoint/number of dogs examined at a given timepoint.