TABLE 5.
Proportion of proteinuric dogs achieving urinary protein‐to‐creatinine ratio (UPC) ≤ 0.5 in response to treatment with PO administered enalapril or telmisartan at progressively greater dosages to target this outcome
| Proportion of dogs achieving UPC ≤0.5 | Odds ratio | P‐value | ||
|---|---|---|---|---|
| Enalapril group | Telmisartan group | |||
| Day 30 | 2/17 (12%) | 6/20 (30%) | 3.2 | .25 |
| Day 60 | 2/12 (17%) | 2/13 (15%) | 0.9 | 1 |
| Day 90 | 1/9 (11%) | 7/8 (13%) | 1.1 | 1 |
| Day 120 | 8/12 (67%) | 9/13 (69%) | 1.1 | 1 |
| Monotherapy (various dosages) | 5/6 (83%) | 8/10 (80%) | ||
| Second drug added | 3/6 (50%) | 1/3 (33%) | ||
| Maximum‐tolerated dosage | 5/16 (31%) | 9/19 (47%) | 2.0 | .47 |
Note: Dogs achieving UPC ≤0.5 at earlier time points were not reevaluated until day 120. Data are presented as number of dogs achieving the endpoint/number of dogs examined at a given timepoint.