TABLE 8.
Summary of owner‐reported adverse events from telmisartan‐treated (n = 20) and enalapril‐treated (n = 19) dogs
| Adverse events | Enalapril monotherapy | Telmisartan monotherapy | Combination therapy | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 0.5 mg/kg q12h | 1.0 mg/kg q12h | 1.5 mg/kg q12h | 1 mg/kg q24h | 2 mg/kg q24h | 3 mg/kg q24h | Enalapril, 1.5 mg/kg q12h + telmisartan, 1 mg/kg q24h | Telmisartan, 3 mg/kg q24h + enalapril 0.5 mg/kg q12h | ||
| Activity | Lethargy/decreased activity | 2 | – | – | 2 | 1 | – | – | 1 |
| Somnolence | 1 | – | – | 1 | – | – | – | – | |
| Irritability | – | – | 1 | – | – | – | – | – | |
| Appetite | Inappetence | 6 | 1 | 2 | 4 | 4 | 2 | 2 | 5 |
| Increased appetite | 1 | 2 | – | – | – | – | – | – | |
| Gastro‐intestinal | Vomiting | 3 | 1 | 2 | 4 | 1 | 2 | 1 | – |
| Diarrhea | 2 | 1 | – | 6 | 2 | 2 | 1 | – | |
| Urinary | Polyuria/Polydipsia | 2 | – | 1 | – | – | – | – | – |
| Pollakiuria | 1 | – | – | – | – | – | – | – | |
| Urinary incontinence | 1 | 2 | – | 1 | – | – | – | – | |
| Nocturia | – | – | – | 1 | – | – | – | – | |
| Pigmenturia | – | – | – | – | – | 1 | – | – | |
| Decreased urination | – | – | – | 1 | – | – | – | – | |
| Urinary tract infection | – | – | – | 1 | – | – | – | – | |
| Respiratory | Cough | 1 | – | – | – | 1 | – | – | – |
| Reverse sneezing | 1 | – | – | – | – | – | – | – | |
| Dermatologic | Pruritus | – | 1 | – | – | – | – | – | – |
| Aural hematoma | – | 1 | – | – | – | – | – | – | |
| Acute moist dermatitis | – | – | – | 1 | – | – | – | – | |
| Other | Corneal ulcer | – | – | 1 | – | – | – | – | – |
| Tooth root abscess | – | 1 | – | – | – | – | – | – | |
| Ataxia | 1 | – | – | – | – | – | – | – | |
| Lameness | – | – | – | – | 1 | – | – | – | |
| Vestibular disease | – | – | – | 1 | – | – | – | – | |
Note: Data are presented as number of dogs for which each event was reported.