TABLE 1.
Laboratory variables and serum vitamin D metabolite concentrations of dogs with PLN and healthy control dogs. Results are presented as median (range). Results with P‐values <.05 are bolded
| Variable (reference range) | Dogs with PLN (n = 23) | Control dogs (n = 10) | P‐value |
|---|---|---|---|
| Age (years) | 9.9 (3.0‐13.5) | 4.3 (1.4‐10.3) | <.001 |
| Sex | |||
| Female | 4 (40%) | 17 (74%) | .11 |
| Male | 6 (60%) | 6 (26%) | |
| BCS | 7 (4‐9) | 6 (4.5‐8) | .07 |
| Body weight (kg) | 10.2 (2‐43) | 26.2 (13.5‐47) | .01 |
| Hematocrit (37%‐56%) | 47 (30‐62) | 51 (45‐55) | .18 |
| BUN (5‐20 mg/dL) | 18 (6‐58) | 18.5 (14‐23) | 1.0 |
| Creatinine (0.6‐1.6 mg/dL) | 0.7 (0.5‐1.2) | 1.0 (0.8‐1.2) | .006 |
| Phosphorus (3.2‐8.1 mg/dL) | 3.9 (2.7‐8.1) | 4.0 (2.7‐5.6) | .89 |
| Albumin (2.9‐4.2 g/dL) | 3.1 (0.9‐4.1) | 3.7 (3.0‐4.0) | .01 |
| USG | 1.020 (1.007‐1.065) | 1.043 (1.031‐1.053) | <.001 |
| UPC | 4.8 (1.7‐27.5) | 0.1 (0.1‐0.1) | <.001 |
| BP (mm Hg) | 160 (120‐240) | 137 (100‐180) | .03 |
| Serum 25(OH)D (ng/mL) | 42.2 (2.5‐68.5) | 75.1 (50.4‐97.9) | <.001 |
| Serum 1,25(OH)2D (pg/mL) | 151.8 (8.9‐313.3) | 209.6 (168.9‐428) | .003 |
| Serum 24,25(OH)2D (ng/mL) | 13.2 (0.3‐31.3) | 38.7 (24‐89.5) | <.001 |
| Urine 25(OH)D (pg/mL) (n = 20) | 1630.25 (475.7‐11 635.0) | N/A | |
| Urine 25(OH)D: creatinine ratio (pg/mg) (n = 20) | 28.44 (5.48‐181.62) | N/A | |
| Serum VDBP (μg/mL) | 200.45 (97.6‐541.9) (n = 16) | 146.1 (95.6‐305.4) (n = 9) | .10 |
| 1,25(OH)2D:25(OH)D (pg/ng) | 3.68 (1.56‐9.38) | 3.21 (2.06‐4.67) | .29 |
| 25(OH)D:24,25(OH)2D | 2.96 (1.42‐8.33) | 1.89 (1.02‐2.42) | <.001 |
Abbreviations: BCS, body condition score; BUN, blood urea nitrogen; PLN, protein‐losing nephropathy; UPC, urine protein‐to‐creatinine ratio; USG, urine‐specific gravity; VDBP, vitamin D binding protein.