Table 2.

Fold regulation of gene expression in CCL3^−/−mice compared to wild-type mice at day 7 or 21 after SCI

Gene	Fold regulation	p value	Function
Day 7
B2m (Beta 2 microglobulin)	− 2.97	0.046	Component of MHC class I molecule [46]
Bmp7 (Bone morphogenetic protein 7)	− 3.24	0.036	Anti-inflammatory protein, neuroprotective function [47, 48]
CCl4 (CCL4)	− 5.27	0.009	CCR1 agonist, role in wound repair and inflammation [49]
Ccl11 (CCL11, eotaxin-1)	− 5.98	0.021	Eosinophil chemotactic protein [50]
CCl12 (CCL12)	− 4.39	0.035	Pro-inflammatory cytokine [51]
Cd70 (CD70)	− 3.52	0.009	Pro-inflammatory, promoting T cell responses [52]
Cx3cl1 (CX3CL1, Fractalkine)	− 5.36	0.003	Chemotactic cytokine [53]
Ifna2 (IFNα2)	− 5.3	0.003	Pro-inflammatory cytokine with role in anti-tumor immunity [54]
Il12b (IL12p40)	− 4.90	0.008	Pro-inflammatory cytokine [55]
Il16 (IL16)	− 9.67	0.049	Chemoattractant for lymphocytes and macrophages [56]
Il17f (IL17F)	− 5.24	0.001	Pro-inflammatory cytokine [57]
Il1a (IL1α)	− 2.25	0.002	Pro-inflammatory cytokine [58]
Il1rn (IL1 receptor antagonist)	− 13.93	0.015	Anti-inflammatory protein [59]
Il27 (IL27)	− 3.16	0.019	Anti-inflammatory protein [60]
Mif (Macrophage migration inhibitory factor)	− 2.54	0.005	Pro-inflammatory cytokine [61]
Osm (Oncostatin M)	− 8.96	0.041	Protein with role in inflammation, hematopoiesis [62]
Thpo (Thrombopoietin)	− 19.65	0.008	Megakaryocyte growth and development factor [63]
Tnf (TNF)	− 3.85	0.034	Pro-inflammatory cytokine [64]
Day 21
Bmp6 (Bone morphogenetic protein 6)	− 2.32	0.034	Iron metabolism [65]
Ifng (IFNγ)	− 4.2	0.031	Pro-inflammatory cytokine [66]
Pf4 (Platelet factor 4/CXCL4)	− 2.76	0.008	Pro-inflammatory chemokine [67]
Thpo (Thrombopoietin)	− 2.89	0.036	Megakaryocyte growth and development factor [63]
Tnfrsf11b (Osteoprotegerin)	− 14.42	0.031	Inhibitor of osteoclast function [68]

Gene expression changes were assessed using RT2 profiler cytokine array (PAMM-150Z), n = 3 mice/group and time point