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. 2020 Nov 27;17:361. doi: 10.1186/s12974-020-02028-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The combination of MS-275 and resveratrol is neuroprotective two days after pMCAO. (a) Treatment with MS-275 (20 μg/kg) and resveratrol (680 μg/kg) reduced the infarct volume, determined 2 days after pMCAO. Silver-stained coronal brain sections showing infarcts in light grey are depicted on top of the panel. ANOVA, **P<0.01 ***P<0.001 (Bonferroni post hoc test). Values are means ± s.e.m. (n = 9-11 from five independent experiments). (b) In the corner test, vehicle-, MS-275- and resveratrol-treated mice showed a preference to turn to the right side 2 days after pMCAO. Treatment with MS-275 and resveratrol reduced this preference for right turns. The dashed line indicates the expected behaviour without a side preference. Two-way repeated-measures ANOVA, *P<0.05, ***P<0.001 (Bonferroni post hoc test). Values are means ± s.e.m. (n = 11-13 from five independent experiments). (c) Treatment with MS-275 and resveratrol improved the latency to move that was increased 2 days after pMCAO. Two-way repeated-measures ANOVA, *P<0.05 (Bonferroni post hoc test). Values are means ± s.e.m. (n = 11-13 from five independent experiments).