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. 2020 Nov 27;17:361. doi: 10.1186/s12974-020-02028-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — The combination of MS-275 and resveratrol reduces immunoreactivity for CD45 1 day after pMCAO. (a) Representative images of CD45 immunoreactivity in the peri-infarct area of brain sections obtained from the contralateral and ipsilateral hemispheres of MCAO vehicle, and from the ipsilateral hemisphere of MCAO MS-275 (20 μg/kg) + resveratrol (680 μg/kg) mice. Scale bar: 120 μm. (b) Quantification of CD45 immunostaining displays an effect of MS-275 and resveratrol treatment in reducing leukocytes infiltration. Data (means ± s.e.m. of 36-48 frames/mouse, n = 3) are expressed as CD45 positive area in the ipsilateral hemisphere/ CD45 positive area in the contralateral hemisphere. Mann Whitney test, *p < 0.05.