Table 4.
Consumption of diabetes medications in 2016 and 2017.
| N of users (N of purchases) | Total consumption, DDDs | Purchases/patient (SD) | DDDs/patient/purchase (SD) | DDDs/patient/year (SD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2016 | 2017 | 2016 | 2017 | 2016 | 2017 | P value | 2016 | 2017 | P value | 2016 | 2017 | P value | |
| All patients (n = 8143) | 7116 (55,104) | 7036 (58,212) | 12,065 | 11,621 | 7.7 (7.5) | 8.3 (8.2) | < 0.001 | 79.9 (61.3) | 72.9 (59.4) | < 0.001 | 618.9 (487.8) | 602.9 (475.6) | 0.048 |
| Patients alive on Jan 1, 2018 (n = 8025) | 6793 (52,050) | 6780 (56,764) | 11,619 | 11,446 | 7.7 (7.4) | 8.4 (8.2) | < 0.001 | 81.5 (60.9) | 73.6 (59.3) | < 0.001 | 624.3 (489.0) | 616.2 (477.2) | 0.326 |
| Subgroup analyses: | |||||||||||||
| Used only metformin in 2016 (n = 2271) | 2271 (9632) | 2184 (10,036) | 1678 | 1681 | 4.2 (4.2) | 4.6 (4.6) | 0.007 | 63.6 (42.6) | 61.1 (42.2) | < 0.001 | 269.6 (129.0) | 280.9 (145.4) | 0.006 |
| Used metformin and other OAD in 2016 (n = 1430) | 1430 (12,946) | 1412 (14,009) | 2806 | 2700 | 9.1 (7.7) | 9.9 (8.7) | 0.005 | 79.1 (44.0) | 70.3 (44.9) | < 0.001 | 716.3 (268.6) | 697.9 (299.2) | 0.084 |
| Used only other diabetes medications than insulin or metformin in 2016 (n = 726) | 726 (4009) | 694 (4316) | 714 | 701 | 5.5 (5.3) | 6.2 (5.6) | 0.016 | 65.0 (41.9) | 59.3 (39.7) | < 0.001 | 358.8 (169.4) | 368.6 (193.9) | 0.309 |
| Used insulin and OAD (incl. metformin) in 2016 (n = 2112) | 2112 (25,656) | 2088 (26,503) | 6046 | 5745 | 12.1 (9.0) | 12.7 (9.8) | 0.061 | 86.0 (72.3) | 79.2 (70.7) | < 0.001 | 1044.9 (572.1) | 1004.9 (559.7) | 0.022 |
| Used only insulin in 2016 (n = 577) | 577 (2861) | 548 (2893) | 821 | 737 | 5.0 (2.5) | 5.3 (3.2) | 0.064 | 104.8 (77.0) | 93.0 (70.4) | < 0.001 | 519.6 (440.6) | 490.8 (413.1) | 0.259 |
| Patients alive on Oct 1, 2019 (n = 7669) | 6730 (51,486) | 6721 (56,235) | 11,526 | 11,372 | 7.7 (7.3) | 8.4 (8.2) | < 0.001 | 81.7 (60.7) | 73.8 (59.3) | < 0.001 | 625.1 (488.6) | 617.6 (477.9) | 0.366 |
Abbreviations: DDD defined daily dose, OAD oral antidiabetic drug