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KLHL18 acts as an adaptor protein to interact with CUL3 and PI3Kp85α through different domains. a Locations of the deletions of KLHL18 domains. b Expression efficiency of KLHL18 splice variants in HEK-293 T cells. c Co-IP using the spliced variants of KLHL18 indicated that CUL3 bound to the BTB domain, whereas PI3Kp85α bound to the non-BTB domain. d The potential mechanism through which KLHL18 exerts its effects in NSCLC cell lines
