Table 2.
Results of univariate analyses for liver cirrhosis risk in chronic hepatitis B patients.
| Variable | n (%) | OR | 95% CI | p-Value |
|---|---|---|---|---|
|
Age >50 years ≤50 years |
346 (53%) 306 (47%) |
4.19 | 2.71–6.48 | <0.001 |
|
Sex Female Male |
242 (37%) 410 (63%) |
1.59 | 1.07–2.36 | 0.021 |
|
Alcohol consumption YES NO |
332 (51%) 320 (49%) |
2.37 | 1.58–3.55 | <0.001 |
|
Previous treatment YES NO |
308 (47%) 344 (53%) |
2.64 | 1.73–4.02 | <0.001 |
|
Portal hypertension YES NO |
254 (39%) 398 (61%) |
515 | 71–3756 | <0.001 |
|
AST >50 IU/L ≤50 IU/L |
118(18%) 534 (82%) |
3.10 | 1.76–58.44 | <0.001 |
|
ALT >42 IU/L ≤42 IU/L |
98 (15%) 554 (85%) |
1.22 | 0.80–1.84 | 0.34 |
|
PLT >150 IU/L ≤150 IU/L |
502 (77%) 150 (23%) |
4.96 | 3.18–7.73 | <0.001 |
|
HBV DNA >6000 kIU/mL ≤6000 kIU/ml |
529 (81%) 123 (19%) |
3.75 | 1.70–8.26 | 0.001 |
|
AST/ALT >1 ≤1 |
254 (39%) 398 (61%) |
1.73 | 1.18–2.53 | 0.004 |
| XRCC1 rs25487 | ||||
| CC vs. TT | 294 (74%) vs. 104 (26%) | 1.58 | 0.95–2.60 | 0.069 |
| CC vs. CT, TT | 294 (45%) vs. 358 (55%) | 0.61 | 0.42–0.89 | 0.012 |
| TT vs. CT, CC | 104 (16%) vs. 548 (84%) | 1.03 | 0.63–1.70 | 0.89 |
| ERCC2 rs238406 | ||||
| GG vs. TT | 235 (60.5%) vs. 154 (39.5%) | 1.58 | 0.91–2.72 | 0.099 |
| GG vs. GT, TT | 235 (36%) vs. 417 (64%) | 1.14 | 0.75–1.73 | 0.54 |
| TT vs. GT, GG | 154 (23.5%) vs. 498 (76.5%) | 0.53 | 0.30–0.92 | 0.025 |
| ERCC2 rs13181 | ||||
| TT vs. GG | 303 (72%) vs. 117 (28%) | 4.27 | 1.11–16.42 | 0.034 |
| GG vs. GT, TT | 117 (18%) vs. 535 (82%) | 1.35 | 0.86–2.14 | 0.19 |
| TT vs. GT, GG | 303 (46.5%) vs. 349 (53.5%) | 0.91 | 0.63–1.33 | 0.64 |
| ERCC5 rs2018836 | ||||
| GG vs. AA | 333 (79%) vs. 88 (21%) | 1.28 | 0.77–2.12 | 0.33 |
| GG vs. GA, AA | 333 (51%) vs. 319 (49%) | 1.41 | 0.86–2.30 | 0.17 |
| AA vs. GA, GG | 88 (13.5%) vs. 564 (86.5%) | 0.92 | 0.61–1.32 | 0.65 |
| RAD 52 rs7963551 | ||||
| TT vs. GG | 492 (87%) vs. 72 (13%) | 1.04 | 0.80–1.25 | 0.97 |
| TT vs. TG, GG | 492 (75.5%) vs. 160 (24.5%) | 0.97 | 0.61–1.54 | 0.91 |
| GG vs. TG, TT | 72 (11%) vs. 580 (89%) | 0.96 | 0.51–1.81 | 0.90 |
| MRE 11 rs496797 | ||||
| TT vs. CC | 163 (44%) vs. 209 (56%) | 0.67 | 0.42–1.09 | 0.11 |
| TT vs. TC, CC | 163 (25%) vs. 489 (75%) | 1.17 | 0.78–1.76 | 0.44 |
| CC vs. TC, TT | 209 (32%) vs. 443 (68%) | 0.68 | 0.45–1.003 | 0.067 |
| MRE 11 rs535801 | ||||
| CC vs. TT | 316 (77%) vs. 95 (23%) | 1.10 | 0.67–1.82 | 0.70 |
| CC vs. CT, TT | 316 (48.5%) vs. 336 (51.5%) | 1.04 | 0.72–1.50 | 0.84 |
| TT vs. CT, CC | 95 (14.5%) vs. 557 (85.5%) | 1.30 | 0.80–2.10 | 0.29 |
| NBN rs2735383 | ||||
| CC vs. GG | 336 (77%) vs. 101 (23%) | 0.59 | 0.35–1.01 | 0.056 |
| CC vs. CG, GG | 336 (51.5%) vs. 316 (48.5%) | 1.29 | 0.88–1.89 | 0.18 |
| GG vs. CG, CC | 101 (15.5%) vs. 551 (84.5%) | 0.53 | 0.29–0.98 | 0.042 |
| XRCC4 rs1805377 | ||||
| GG vs. AA | 522 (97.5%) vs. 13 (2.5%) | 1.51 | 0.71–3.21 | 0.28 |
| GG vs. GA, AA | 522 (80%) vs. 130 (20%) | 0.85 | 0.54–1.32 | 0.46 |
| AA vs. GA, GG | 13 (2%) vs. 639 (98%) | 2.15 | 7.44–6.22 | 0.16 |
p-values less than 0.05 are marked in bold. CI, confidence interval; OR, odds ratio.