Table 4.
Permeation parameters for the 0.1% rapamycin formulations.
| Formulation | Jss (µg cm−2 h−1) 1 |
Kp × 10−4 (cm h−1) 1 |
Tlag (h) 1 |
D × 10−5 (cm2 h−1) 1 |
P skin/vehicle 1 | Cumulative Amount Diffused at 24 h (µg cm−2) 1 |
|---|---|---|---|---|---|---|
| F1 | ND | ND | ND | ND | ND | <LOD |
| F2 | 0.1 ± 0.03 °*§ | 1.2 ± 0.3 °*§ | 13.3 ± 0.8 °*§ | 1.1 ± 0.07 °*§ | 0.3 ± 0.04 °*§ | 1.3 ± 0.4 °*§ |
| F3 | 0.7 ± 0.05 φ† | 6.8 ± 0.5 φ† | 5.1 ± 0.5 φ | 3.0 ± 0.3 φ | 0.7 ± 0.05 φ† | 12.8 ± 1.2 φ† |
| F4 | 0.5 ± 0.06 ◊ | 5.1 ± 0.6 ◊ | 1.1 ± 0.3 ◊ | 12.0 ± 1.2 ◊ | 0.1 ± 0.01 ◊ | 10.0 ± 1.2 ◊ |
| F5 | 0.8 ± 0.08 | 7.9 ± 0.8 | 4.8 ± 0.6 | 3.2 ± 0.4 | 0.8 ± 0.06 | 15.3 ± 1.5 |
1 Data are represented as mean ± standard deviation of 6 assays (n = 6). ° F2 versus F3, * F2 versus F4, § F2 versus F5: p < 0.05; φ F3 versus F4, † F3 versus F5: p < 0.05; ◊ F4 versus F5: p < 0.05. ND: not determined; LOD: limit of detection; Jss: steady-state flux; Kp: permeability coefficient; Tlag: lag time; D: diffusion coefficient (thickness set at 300 µm); Pskin/vehicle: partition coefficient between skin and vehicle.