Table 4.
Area under the receiver operating characteristic curve of predicted probabilities of developing clinical malaria for single antibody responses to 11 Plasmodium falciparum antigens and combination antibody responses to select antigens CSP, GLURP-R0, GLURP-R2, and LSA-1
| Antigens | AUROC (95% CI) dichotomous | AUROC (95% CI) continuous |
|---|---|---|
| CSP, GLURP-R0, GLURP-R2, and LSA-1 | 0.6605 (0.6117–0.7093) | 0.6664 (0.6173–0.7155) |
| CSP, GLURP-R2, and LSA-1 | 0.6586 (0.6095–0.7078) | 0.6655 (0.6162–0.7148) |
| GLURP-R0, GLURP-R2, and LSA-1 | 0.6528 (0.6049–0.7007) | 0.6617 (0.6137–0.7097) |
| CSP, GLURP-R0, and GLURP-R2 | 0.6505 (0.6017–0.6993) | 0.6610 (0.6117–0.7104) |
| CSP and GLURP-R2 | 0.6468 (0.5976–0.6960) | 0.6600 (0.6106–0.7095) |
| GLURP-R2 and LSA-1 | 0.6531 (0.6052–0.7011) | 0.6592 (0.6112–0.7071) |
| CSP, GLURP-R0, and LSA-1 | 0.6551 (0.6057–0.7046) | 0.6548 (0.6050–0.7046) |
| CSP and LSA-1 | 0.6495 (0.5998–0.6992) | 0.6548 (0.6050–0.7046) |
| GLURP-R0 and GLURP-R2 | 0.6417 (0.5936–0.6898) | 0.6527 (0.6044–0.7010) |
| GLURP-R2 | 0.6385 (0.5904–0.6867) | 0.6521 (0.6038–0.7003) |
| LSA-1 | 0.6428 (0.5943–0.6912) | 0.6472 (0.5991–0.6953) |
| GLURP-R0 and LSA-1 | 0.6451 (0.5969–0.6933) | 0.6463 (0.5982–0.6944) |
| CSP and GLURP-R0 | 0.6373 (0.5875–0.6872) | 0.6396 (0.5891–0.6901) |
| CSP | 0.6281 (0.5779–0.6784) | 0.6351 (0.5842–0.6860) |
| GLURP-R0 | 0.6296 (0.5804–0.6787) | 0.6294 (0.5805–0.6784) |
| AMA-1 3D7 | 0.6254 (0.5763–0.6745) | 0.6287 (0.5793–0.6781) |
| Erythrocyte-binding protein-2 | 0.6297 (0.5807–0.6786) | 0.6223 (0.5727–0.6718) |
| MSP-142 FVO | 0.6307 (0.5807–0.6806) | 0.6206 (0.5711–0.6702) |
| AMA-1 FVO | 0.6228 (0.5736–0.6719) | 0.6204 (0.5710–0.6699) |
| Erythrocyte-binding antigen-175 | 0.6183 (0.5686–0.6679) | 0.6203 (0.5708–0.6697) |
| MSP-3 | 0.6244 (0.5757–0.6731) | 0.6197 (0.5704–0.6691) |
| MSP-142 3D7 | 0.6208 (0.5711–0.6704) | 0.6194 (0.5699–0.6690) |
AMA = apical membrane antigen; AUROC = area under the receiver operating characteristic curve; CSP = circumsporozoite protein; GLURP-R0 = glutamate-rich protein N-terminal non-repetitive region; GLURP-R2 = glutamate-rich protein C-terminal repetitive region; LSA = liver-stage antigen; MSP = merozoite surface protein.
Rows are sorted in decreasing order of AUROC, treating antibody response as a continuous measure.