Table 2.
Changes in antibody seropositivity and levels between collections in April 2009 (before spike in malaria incidence) and May 2010 (after spike in malaria incidence)
| Antigen | Geometric mean antibody level (arbitrary unit) | Proportion seropositive | ||||
|---|---|---|---|---|---|---|
| April 2009 | May 2010 | P-value | April 2009 | May 2010 | P-value | |
| Strongly immunogenic | ||||||
| Apical membrane antigen 1 | 8.09 (6.52, 10.04) | 6.26 (4.96, 7.90) | 0.968 | 0.76 (0.72, 0.79) | 0.73 (0.69, 0.77) | 0.971 |
| Erythrocyte-binding antigen 175 | 2.64 (2.07, 3.38) | 2.19 (1.69, 2.83) | 0.968 | 0.61 (0.56, 0.65) | 0.57 (0.52, 0.62) | 0.971 |
| Erythrocyte-binding protein-2 | 1.40 (1.14, 1.72) | 1.11 (0.90, 1.37) | 0.968 | 0.50 (0.46, 0.54) | 0.44 (0.39, 0.48) | 0.971 |
| GLURP-R2 | 2.96 (2.47, 3.54) | 2.54 (2.10, 3.08) | 0.968 | 0.68 (0.63, 0.72) | 0.67 (0.62, 0.71) | 0.971 |
| Liver-stage antigen-1 | 1.43 (1.26, 1.62) | 1.38 (1.21, 1.58) | 0.968 | 0.59 (0.55, 0.63) | 0.59 (0.54, 0.63) | 0.971 |
| MSP-1 (19) | 11.34 (9.02, 14.25) | 10.52 (8.39, 13.19) | 0.968 | 0.75 (0.71, 0.78) | 0.77 (0.72, 0.80) | 0.852 |
| MSP-1 (42) | 8.29 (6.71, 10.24) | 7.24 (5.78, 9.07) | 0.968 | 0.76 (0.73, 0.80) | 0.76 (0.72, 0.80) | 0.971 |
| Moderately immunogenic | ||||||
| GLURP-R0 | 0.45 (0.39, 0.52) | 0.41 (0.35, 0.48) | 0.968 | 0.31 (0.27, 0.35) | 0.28 (0.24, 0.33) | 0.971 |
| MSP-3 | 0.56 (0.49, 0.64) | 0.47 (0.41, 0.54) | 0.968 | 0.35 (0.31, 0.39) | 0.31 (0.27, 0.35) | 0.971 |
| Thrombospondin-related adhesive protein | 0.43 (0.38, 0.47) | 0.48 (0.42, 0.55) | 0.295 | 0.24 (0.20, 0.28) | 0.29 (0.25, 0.34) | 0.151 |
| Poorly immunogenic | ||||||
| Circumsporozoite protein | 0.46 (0.45, 0.48) | 0.58 (0.55, 0.61) | < 0.0001 | 0.05 (0.03, 0.07) | 0.09 (0.07, 0.12) | 0.056 |
| Schizont extract | 0.38 (0.38, 0.39) | 0.64 (0.61, 0.66) | < 0.0001 | 0.00 (0.00, 0.01) | 0.18 (0.15, 0.22) | < 0.0001 |
GLURP = Glutamate rich protein; MSP = Merozoite surface protein. P-values for antibody levels are calculated using a one-sided t-test for an increase between April 2009 and May 2010. P-values for proportion seropositive are calculated using a one-sided two-proportions Z-test for an increase between April 2009 and May 2010. P-values have been corrected for multiple hypothesis testing using the Benjamini–Hochberg procedure. Note: this procedure does not allow adjusted P-values to take a value greater than the maximum unadjusted P-value.