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Mammalian antiviral RNAi. Dicer cleaves dsRNAs to generate duplex 22mer siRNAs with a 2-nt 3′ overhang, 22mer siRNAs are loaded to Argonaute AGO2 to form RISCs, and RISCs cleave target RNAs. VSR and IFN signaling suppress Dicer activity; VSR also suppresses RISC activity.
