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. 2020 Nov 7;12(11):3297. doi: 10.3390/cancers12113297

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Administration of 5-ALA leads to PpIX fluorescence in vitro and in vivo. (A) Intra-operative view of Glioblastoma resection under white light (top row) and under 405nm light (bottom row). Protoporphyrin IX (PpIX) fluorescence is seen as pink. (B) U87 cells treated with 5-aminovulenic acid (5-ALA) (left panels) show PpIX fluorescence upon excitation at 490nm compared to control (right panels). 40× magnification. (C) Tunable resistive pulse sensing (TRPS) analysis of EVs isolated from U87 cells treated with 5-ALA. n = 2 (D) TRPS analysis of EVs isolated from U87 cells treated with PBS control. n = 2. (E) High-resolution flow cytometry (hFC) analysis of PBS. (F) hFC analysis of PBS with EVs isolated from U87 cells. (G) hFC analysis of PBS with EVs isolated from U87 cells treated with 5-ALA.