Table 1.

Model Constants

Parameter	Definition	Value	Unit	Reference
E0	Initial modulus of cell-laden hydrogel	42	kPa	This study
β	Network connectivity	0.044	--	This study
${\rho }_x^{s,0}$	Initial crosslink density in swollen state	400	µM	This study
rcell	Cell radius	5.75	μm	Ref 39
re	Hydrodynamic radius of enzyme	6.5	nm	Nanocomposix.com
De∞	Diffusivity of enzyme in pure solvent	5.7E-5	mm2/s	Stokes-Einstein
kcat	Enzyme catalytic rate constant	0.05	s−1	This study
KM	Michaelis-Menten constant	20	µM	This study
rm	Hydrodynamic radius of ECM molecules	>200	nm	Ref 40,41
Rd	Radius of degradation	1.5rcell	μm	Ref 42
kd	Enzyme deactivation constant	0.00029	s−1	Model fit
m	ECM stiffness correlation constant	5.0E5	kJ/mol	Model fit