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Blocking cholesterol synthesis due to depletion of Cyp51 resulted in histological alterations of the liver, most prominent in females. (A) Histological examination revealed ductular reaction (*) and inflammation (→) (H&E, original magnification ×200), N = 5–10. (B) Sirius red stain (SR, original magnification ×200) showed more pronounced fibrosis in female transgenic mice, N = 3–5. M, month; KO, Cyp51 KO; WT, wild-type.
