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. 2020 Nov 9;12(11):3303. doi: 10.3390/cancers12113303

Figure 2.

Figure 2

Glioblastoma organoids. (A) Cerebral organoids, derived from pluripotent stem cells (PSCs) or embryonic stem (ES) cells, can be genetically engineered introducing tumor-promoting mutations or oncogenes and green fluorescent protein (GFP) to visualize tumor growth. NeoCOR, neoplastic cerebral organoids [46,77]. (B) Glioblastoma stem cells (GSCs) marked with GFP have been co-cultured with cerebral organoids to obtain glioma cerebral organoids (GLICO) [77,79]. Patient-derived Glioblastoma (GBM) specimens have been embedded in Matrigel (C) [75] or cultured in Matrigel- and serum-free conditions, on a spinning-bioreactor (D) [76], to obtain GB organoids. Adapted from reference [43].