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. 2020 Nov 9;12(11):1277. doi: 10.3390/v12111277

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Receiver Operating Characteristics (ROC) and their corresponding Area Under the Curve (AUC) assessing the ability of CD3+CD4+T cell count (CD3+CD4+A), CD4+MFI (CD4_MFI) and CD4+/CD8+ ratio (RATIO48) to predict COVID-19 critical clinical evolution. AUC intervals at 95% confidence were computed using bootstrap. Total accuracy, sensitivity, and specificity are displayed for the optimal threshold, defined as the ROC point closest to the top-left part of the plot (perfect sensitivity and specificity).