Table 2.
Association of blood determinations with COVID-19 evolution after statistical control by age, gender, and time from symptoms onset.
| Blood Determinations | Adjusted Means (95% CI) | F-Test | |
|---|---|---|---|
| Non-Critical | Critical | p-Value | |
| Leucocyte count (cells × 109/L) |
7292.5 (5851.2, 9088.9) | 6789.8 (5275.6, 8738.5) | 0.6665 |
| Neutrophyl count (cells × 109/L) |
5167.1 (3921.5, 6808.3) | 4871.5 (3551.3, 6682.3) | 0.7764 |
| Lymphocyte count (cells × 109/L) |
1281.7 (1081.5, 1519.0) | 1209.2 (995.3, 1468.9) | 0.6487 |
| Ratio N/L | 4.03 (2.89, 5.62) | 4.03 (2.75, 5.91) | 0.9980 |
| Ferritin (ng/mL) | 485.2 (290.9, 809.1) | 981.9 (546.5, 1764.2) | 0.0757 |
| CRP (mg/dL) | 7.37 (4.56, 10.84) | 8.93 (5.41, 13.33) | 0.5285 |
| D-Dimer (mg/mL) | 573.9 (426.2, 814.4) | 588.6 (418.3, 888.8) | 0.9175 |
| LDH (U/L) | 268.5 (229.0, 319.2) | 341.4 (280.2, 425.1) | 0.0776 |
| T lymphocyte count | 829.3 (606.8, 1086.5) | 683.3 (456.6, 955.6) | 0.3991 |
| CD3+CD4+ count | 597.8 (445.8, 801.6) | 331.5 (236.9, 464.0) | 0.0122 |
| CD3+CD8+ count | 214.8 (153.1, 301.5) | 217.2 (147.3, 320.3) | 0.9659 |
| CD3+CD4+CD8+ count | 15.4 (9.8, 24.3) | 11.5 (6.8, 19.5) | 0.4027 |
| CD3+CD4−CD8− count | 19.3 (12.4, 30.1) | 10.7 (6.4, 17.7) | 0.0840 |
| B Lymphocyte count | 129.7 (92.5, 173.3) | 101.9 (65.0, 147.0) | 0.3356 |
| Natural Killer count | 198.0 (148.9, 254.1) | 199.4 (143.5, 264.4) | 0.9725 |
| Ratio CD4+/CD8+ | 2.65 (2.01, 3.50) | 1.49 (1.08, 2.05) | 0.0010 |
| CD4+ MFI | 26128 (24878, 27441) | 22416 (21192, 23712) | 0.0003 |
| CD8+ MFI | 26076 (23953, 28386) | 25863 (23465, 28506) | 0.8980 |
Ratio N/L: ratio neutrophil to lymphocyte; CRP: C-reactive protein, LDH: lactate dehydrogenase; MFI: median fluorescence intensity; PCC: Partial Correlation Coefficient; CI: confidence interval. Adjusted group means, their 95% confidence intervals (CI) and F-test p-values derived from a linear model are showed.