Table A1.
Results of neurocognitive assessments highlighting cognitive difficulties.
| Patient | Age at Testing (y) | Time from Onset (m) | FSIQ | WMI | PSI | WR | PD | Sp | NO | VMI | VP | MC | MSI | MSD | Any Impairment |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 * | 8 | 24 | −3.1 | −2.5 | −1.5 | −1.5 | −0.6 | −1.2 | −3.7 | −1.4 | −2.5 | −2.7 | −1.7 | −1.3 | 1 |
| 3 | 16 | 55 | −2.0 | −2.3 | −3.3 | −1.4 | −1.6 | −0.9 | −3.2 | −2.8 | −3.1 | −3.6 | - | - | 1 |
| 7 * | 14 | 24 | 1.3 | 0.9 | 1.2 | 1.1 | 0.7 | 1.0 | 1.5 | −0.1 | −0.1 | −0.4 | −1.0 | −1.0 | |
| 9 * | 15 | 21 | 1.3 | −0.2 | 1.7 | 0.1 | −0.5 | −0.7 | 1.5 | −0.7 | −0.3 | 0.0 | 1.0 | 0.0 | |
| 10 | 15 | 31 | - | - | - | - | - | - | −0.9 | - | - | - | - | - | |
| 13 * | 13 | 30 | 1.5 | −0.9 | −1.8 | 0.3 | −0.3 | 0.1 | −0.3 | −0.7 | 0.0 | −2.4 | - | - | 1 |
| 14 * | 6 | 34 | 1.5 | −2.3 | −0.2 | −2.7 | −1.3 | −2.1 | 0.0 | −0.2 | −0.5 | −2.0 | - | - | 1 |
| 15 | 14 | 58 | - | −0.2 | −0.6 | 0.5 | 0.8 | −0.3 | −0.3 | 0.3 | −0.1 | 0.4 | −1.3 | −1.7 | |
| 16 | 11 | 11 | - | −2.1 | −2.3 | - | - | - | - | - | - | - | −0.7 | −1.0 | 1 |
| 17 | 12 | 73 | −2.4 | −1.5 | −1.7 | −0.3 | - | −0.3 | −1.9 | - | - | - | −1.0 | −0.3 | 1 |
| 20 | 19 | 34 | −0.1 | 0.1 | −1.6 | - | - | - | - | - | - | - | - | - | |
| 21 | 15 | 11 | −1.9 | −3.3 | −2.5 | −1.3 | - | −0.7 | −0.2 | - | - | - | −0.7 | −0.7 | 1 |
| 22 | 16 | 27 | −0.3 | 1.1 | −1.5 | - | - | - | - | - | - | - | −1.0 | −1.7 | |
| 24 | 15 | 22 | 1.4 | 0.1 | 1.7 | - | - | - | - | - | - | - | - | - | |
| 25 | 14 | 7 | −0.3 | 0.0 | −1.1 | 0.4 | 0.5 | −0.5 | 0.5 | −0.2 | −1.3 | −1.1 | 0.7 | 0.3 | |
| 26 | 11 | 53 | −0.8 | −0.7 | −0.7 | 0.9 | 0.9 | −0.7 | −0.2 | 0.3 | 0.3 | −0.7 | −0.7 | −0.3 | |
| 27 * | 15 | 33 | 0.5 | 0.9 | −0.2 | 0.7 | 0.9 | 0.5 | 0.7 | −1.1 | −0.1 | −0.7 | - | - | |
| 28 | 17 | 42 | −0.7 | 0.7 | −0.7 | 0.5 | 1.2 | 1.0 | 0.9 | −0.3 | −0.1 | −0.4 | - | - | |
| 29 | 16 | 40 | −0.5 | −1.1 | −0.5 | 0.5 | 0.7 | 0.1 | 1.6 | −0.3 | −1.2 | −1.3 | - | - | |
| 31 | 14 | 5 | −0.7 | −1.0 | 0.0 | −1.7 | −1.3 | −1.2 | −1.8 | −0.3 | −2.9 | −1.3 | −1.0 | −1.7 | 1 |
| 32 * | 16 | 33 | −0.7 | −0.5 | 0.0 | 0.1 | 0.7 | 0.3 | 0.3 | −0.9 | −0.4 | −1.0 | −1.0 | −1.0 | |
| 33 * | 17 | 31 | 0.4 | 1.2 | −0.4 | 1.1 | 0.7 | 1.1 | 1.3 | −0.7 | −0.2 | −1.0 | - | - | |
| 34 | 7 | 25 | 0.7 | 0.0 | 0.9 | 1.3 | - | - | - | −0.1 | - | - | - | - | |
| 35* | 8 | 17 | −0.1 | 0.7 | −0.4 | 1.0 | 0.5 | 0.5 | −1.0 | −0.4 | 0.4 | −0.9 | 0.0 | −0.7 | |
| 36 | 14 | 4 | −1.4 | 0.3 | −2.5 | −0.5 | −0.9 | −0.7 | 0.1 | −1.1 | −1.6 | −3.6 | −0.7 | −0.7 | 1 |
| 37 | 15 | 10 | −0.9 | −0.5 | −0.9 | 0.9 | 0.5 | −0.1 | −1.5 | −0.3 | 0.1 | −0.1 | −1.0 | −1.0 | |
| 38* | 15 | 23 | −0.6 | −0.2 | −0.9 | 0.6 | −0.7 | 0.7 | 0.1 | −1.4 | 0.1 | −0.1 | 0.7 | 0.7 | |
| 39 | 15 | 25 | 2.1 | 2.7 | 1.5 | 0.7 | 0.8 | 0.5 | 2.0 | −0.3 | 0.6 | 0.4 | 1.7 | 1.3 | |
| 40 | 12 | 18 | −0.6 | −0.7 | −0.6 | 0.0 | - | −0.3 | 1.5 | −0.2 | 0.1 | −0.1 | 0.3 | 0.0 | |
| 41 | 13 | 9 | 0.4 | 0.3 | 0.7 | 0.9 | - | −0.1 | − | −0.3 | −0.2 | 1.1 | −1.7 | −1.3 | |
| 42 | 14 | 14 | −1.7 | −1.7 | −0.9 | −0.1 | - | −0.3 | 1.3 | −2.8 | −2.9 | −2.1 | −1.7 | −1.7 | 1 |
| 43 | 12 | 26 | −1.6 | −1.0 | −0.6 | 0.3 | - | −0.5 | −1.5 | −1.0 | −0.4 | −1.7 | 0.0 | 0.3 | |
| 44 | 15 | 82 | 0.9 | 0.0 | 1.3 | 0.1 | - | 0.0 | 0.2 | −0.7 | 0.1 | −0.9 | 0.0 | 0.0 | |
| 45 | 13 | 25 | 0.1 | 0.3 | 0.2 | 1.5 | - | 1.7 | 0.9 | −0.3 | 0.1 | 0.4 | 0.7 | 0.3 | |
| 46 | 9 | 45 | 0.8 | 0.3 | 1.9 | −0.2 | - | −0.4 | 1.2 | −0.7 | 0.1 | 0.2 | 0.0 | 0.0 | |
| 47 | 14 | 10 | −1.3 | −0.3 | −1.3 | 0.1 | - | −0.7 | −1.0 | −1.1 | −0.7 | −1.0 | −0.7 | −0.7 | |
| 50 | 15 | 19 | 0.5 | −0.3 | 0.6 | 1.2 | - | 1.2 | 0.9 | −0.2 | −0.7 | −2.5 | 1.3 | 1.3 | 1 |
| 51 | 9 | 7 | 0.9 | 0.0 | 0.7 | 0.9 | - | 1.0 | 1.6 | −1.4 | 0.3 | −0.6 | 2.0 | 1.7 |
FSIQ, Full-Scale IQ; WMI, Working Memory Index; PSI, Processing Speed Index; WR, Word Reading; PD, Pseudoword Decoding; Sp, Spelling; NO, Numerical Operations; VMI, Visual–Motor Integration; VP, Visual Perception; MC, Motor Coordination. Asterix (*) indicates patients who had multiple cognitive assessments. Red and blue indicate earlier and later cohorts, respectively. Cognitive results in the “impaired” range are highlighted in yellow.