Figure 6.

Aortic NAD⁺ levels and Sirt1 activity were reduced in AAA and restored by either niacin or nicotinamide supplementation. Aortic NAD⁺ levels in AngII-induced AAA model (A, n = 3) and CaCl₂-induced AAA model (B, n = 3). Sirt1 activities in AngII-induced AAA model (C, n = 3) and CaCl₂-induced AAA model (D, n = 3). Sirt1 protein expression levels in AngII-induced (E, n = 3) and CaCl₂-induced (F, n = 6) AAA models. Data were analysed using one-way ANOVA followed by Bonferroni post hoc analysis. AngII, angiotensin II; CaCl₂, calcium chloride; NA, nicotinic acid; NAD, nicotinamide adenine dinucleotide; Nam, nicotinamide; N.S., not significant; Sirt, sirtuin.