Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation for loss of chromosome cohesion and the generation of single chromatids in MII oocytes as a result of maternal aging. The effect of advanced maternal age is depicted on a bivalent (dark and light blue) during meiosis I. Aging is associated with weakened cohesion (red rings). The increased distance between sister chromatid kinetochores prevents them from working as a single unit. They are therefore subject to random segregation, as opposed to equal segregation.
