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Knockdown of PVT1 suppressed BC cells tumorigenicity. Tumors collected from mice were exhibited (A). The relative expression level of PVT1 was reduced by LV-PVT1 (B). Tumor weight of LV-PVT1 or LV-shNC groups were measured (C). Tumor volume curve of LV-shPVT1 or LV-shNC groups were measured (D). Knockdown of PVT1 down-regulated BCLAF1 etc. expression (E). Knockdown of PVT1 decreased Ki-67 and BCLAF1 expression of BC cells in vivo (F). (*P < 0.05, **P < 0.01).
