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. 2020 Nov 27;9:e60535. doi: 10.7554/eLife.60535

Figure 6. Reward-context modulation of the rate of change in FEF more closely reflected reward bias in drift rates.

(A) Illustration of measurements of different modulations of the rate of change for a single neuron. Left: average firing rates of the example neuron in Figure 2B for its preferred choice and aligned to motion onset. In 200 ms sliding windows, linear regressions were performed to estimate the slope of firing-rate changes as a function of time, coherence, reward context and their combination. Right: slope values for the sliding window in the left panel. A multiple linear regression was performed with coherence, reward context and their interaction as the regressors (lines). The offset between the two reward contexts at zero coherence (filled triangles) represents the magnitude of reward-context modulation in the regression. (B) The regression coefficients of the linear regression for different sliding windows for the example neuron. Filled circle: coefficient was significantly different from zero (t-test, p<0.05). For each neuron, the time with the largest absolute coherence modulation was identified (arrow). For the alignment to motion onset, a minimum 100 ms visual latency was imposed. (C) Coefficient values for FEF (top) and caudate (bottom) neurons with significant coherence-modulated slope values for trials with the preferred choices. (D) Scatter plots of the ratio of regression coefficients for reward context and coherence modulation (abscissa) and the behavioral bias in drift rates (from DDM fits, ordinate), for FEF (top) and caudate (bottom) neurons with significant coherence modulation. Preferred choice only. Slope values were measured from activity aligned to motion (left) and saccade (right) onset. Line and shaded area: linear regression with significant non-zero slope (t-test, p<0.05) and 95% confidence interval. Colors indicate neurons from the three monkeys.

Figure 6—source data 1. Source data for Figure 6D: FEF activity aligned to motion onset.
Figure 6—source data 2. Source data for Figure 6D: FEF activity aligned to saccade onset.
Figure 6—source data 3. Source data for Figure 6D: caudate activity aligned to motion onset.
Figure 6—source data 4. Source data for Figure 6D: caudate activity aligned to saccade onset.

Figure 6.

Figure 6—figure supplement 1. Slope measurements from trials with the non-preferred choices and from neurons without consistent choice selectivity.

Figure 6—figure supplement 1.

(A) Results from trials with the non-preferred (null) choice for the same FEF neuron as in Figure 6A. Same format as Figure 6A. (B) Results from trials with null choices for FEF neurons with significant coherence modulation of the slope of firing rates and consistent choice selectivity. Same format as Figure 6D. (C) Results from FEF neurons without consistent choice selectivity. Same format as Figure 6D, except that trials were separated by contralateral/upward choices and ipsilateral/downward choices. (D) Results from caudate neurons without consistent choice selectivity. Same format as C.
Figure 6—figure supplement 2. Results of correlation analysis as used in Figure 6D, for the three monkeys separately.

Figure 6—figure supplement 2.

Only neurons with consistent choice selectivity and significant coherence selectivity during the motion/saccade epoch were included.