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. 2020 Nov 27;6(48):eaba4905. doi: 10.1126/sciadv.aba4905

Fig. 2. The relationship between germline genomic pattern E and tobacco mutagen sensitivity.

Fig. 2

(A) Germline genomic pattern (CGGP_E) is highly enriched in smoker patients than in nonsmoker patients in nine cancer types (P < 0.1, t test). Gray violin boxes represent nonsmoker patients, while the boxes with other colors represent smoker patients. (B) Relative contributions (i.e., weights) of CGGP_E in germline genomes are significantly correlated to the possession of smoking-related somatic mutational signature 4 (COSMIC signature 4) in their paired tumor genomes. (C) Relative contributions (i.e., weights) of CGGP_E in germline genomes are positively correlated with COSMIC signature 4 in their paired tumors in the TCGA clinical information–defined smokers but not in the TCGA clinical information–defined nonsmokers. Notably, only cancer types with a sizable amount of clinical smoking information (e.g., HNSC, Lung, and PAAD) were considered. N/A, not applicable.