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. 2020 Nov 27;6(48):eaba4905. doi: 10.1126/sciadv.aba4905

Fig. 3. Enrichment of germline CGGPs implied somatic mutations in oncogenic genes in paired tumors.

Fig. 3

Elevated weighing factors of CGGPs are correlated with the higher prevalence of somatic mutations on the 18 most frequently mutated genes across all cancer types. The results for 18 common cancer (sub)types are summarized as a pie chart array. Each small pie chart in the plot is split to seven slots (starting from the top-right slot and going clockwise, CGGP_A to CGGP_G alphabetically). A gray slot indicates that no significant result is observed in corresponding cancer (sub)type and somatically mutated gene pair. An orange or a light blue slot indicates a positive (ratio of mean CGGP weights > 1, mutated samples versus nonmutated samples) or negative (ratio of mean CGGP weights < 1, mutated samples versus nonmutated samples) significant association (FDR < 0.25) of a CGGP and a somatically mutated gene in corresponding cancer (sub)type, respectively. A dark pink or a dark blue slot indicates a high confidence association (FDR < 0.25 and empirical P < 0.05 by 10,000 times of randomization tests) of a CGGP and a somatically mutated gene in corresponding cancer (sub)type, respectively.