Fig. 5. Associations between CGGP-defined subgroups with cancer histological subtypes, oncogenic pathways, and clinical outcomes.

(A) Brain tumor patients were partitioned into subgroups with distinct clinical and biological traits through unsupervised hierarchical clustering of the distribution profile of the genomic patterns in patients’ germ lines. (B) Visualization of tSNE illustrated the subgroups identified in A1. (C) Significant survival differences between the brain subgroups. (D) Significant survival differences between germline subgroups in bladder, breast, cervical, head and neck, kidney, lung, prostate, and uterine cancers. Cancer types with insufficient sample size or without histological diagnosis information were excluded from analyses.