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. 2020 Nov 19;2020:8893305. doi: 10.1155/2020/8893305

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Copyright © 2020 Qin Cao et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(a) The anti-inflammatory effect of 25-HC. 25-HC reduces IL-1 family (IL-1α, IL-1β, and IL-18) release and inflammasome activity via inhibiting SREBP. 25-HC decreases NLRP3 and AIM2 inflammasome formation by reducing mitochondria oxidative stress. Furthermore, NLRP3 associates with SCAP and SREBP2 to form a ternary complex which translocated to the Golgi apparatus adjacent to a mitochondrial cluster for optimal inflammasome assembly, and 25-HC inhibits this process. (b) Proinflammatory effect of 25-HC. 25-HC amplifies the expression of proinflammatory factors (TNFα, IL-6, IL-8, MCP1, and Ccl2) and reduces the anti-inflammatory factor IL-10. 25-HC promotes robust NLRP3 inflammasome assembly and activation via potassium efflux, mitochondrial ROS, and LXR-mediated pathways in brain.