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. 2020 Nov 19;2020:8819771. doi: 10.1155/2020/8819771

Figure 6.

Figure 6

miR-204 targets HMGB1 in DOX-induced cardiac injury. (a) The binding site of miR-204 and HMGB1. (b) The luciferase activity of HMGB1-UTR (HMGB1-WT) or mutant (HMGB1-MUT) in the indicated groups (n = 4), ∗P < 0.05 versus miR-NC. (c) Western blot analysis was performed to measure HMGB1 protein levels in hearts with or without miR-204 (n = 6), ∗P < 0.05 versus NS+GFP and #P < 0.05 versus DOX+GFP. (d) Western blots and quantitative analysis of HMGB1 in each group (n = 6), ∗P < 0.05 versus PBS+miR-NC and #P < 0.05 versus DOX+miR-NC.