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HMGB1 overexpression abolished the anti-inflammatory and antiapoptotic effects of miR-204. (a) The protein expression of HMGB1 after cells were treated with Ad-HMGB1 (n = 6), ∗P < 0.05 vs. Ad-GFP. (b) The mRNA levels of inflammation-related genes (n = 6). (c) LDH level in the indicated groups (n = 6). (d, e) Representative images and quantitative analysis of TUNEL staining (n = 4). ∗P < 0.05 versus control, #P < 0.05 versus DOX+Ad-GFP, and ζP < 0.05 versus DOX+miR-204.
